Yaz birth control skin#

Use of isotretinoin in past six months.Use of intralesional steroids within 30 days.Change is use of oral or topical antibiotics in past 90 days.Able to complete study and comply with study procedures.Willing and able to understand and sign informed consent.Clinical diagnosis of hidradenitis suppurativa of stage II or greater on the Hurley scale.Female Subjects 14-45 years of age who have achieved spontaneous menarche.Safety will be assessed from reported adverse events (AEs). A physical examination will be done at baseline and Week 24. Lesion counts (total, inflammatory, non-inflammatory) and an ISGA, and photography will be performed on every visit. The study duration will be 24 weeks with visits at screening, baseline (week 0), week 6, week 12, week 18, and week 24. Bayer HealthCare Pharmaceuticals personnel, investigators, subjects and study nurse/coordinators will be blinded to the study product treatment assignment. Subjects will be assigned to a treatment group upon randomization. It is hoped that that YAZ will offer patients with hidradenitis suppurativa a safe and effective therapeutic option. The antiandrogenic property of drospirenone means that it blocks the male sex hormones that can cause acne. Unlike other progestins, drospirenone has unique antimineralocorticoid (mild diuretic effect) and antiandrogenic properties. YAZ is an oral contraceptive that is FDA approved for acne vulgaris. Oral contraceptives containing norgestrel or cyproterone acetate, alone or in combination with supplemental cyproterone acetate, spironolactone or dexamethasone (to block adrenal androgen production), have been shown to reduce the frequency and severity of attacks in women. Some patients have had a beneficial response to biological agents, especially anti-TNF alpha biologicals such as infliximab. Oral isotretinoin has been used, but is effective only in some cases. Although many patients benefit from long-term treatment with systemic antibiotics (eg, tetracycline, minocycline, clindamycin, erythromycin in combination with metronidazole), no published evidence suggests that the long-term use of antibiotics alters the natural course of HS. Treating hidradenitis remains a challenge.

Hormones seem to play a role, as the condition occurs after puberty, affects more women than men, and often flares in the perimenstrual period. Proposed etiologic factors include follicular occlusion and bacterial infection, genetics, host defense defects, hormones, cigarette smoking, and irritants. The exact etiology of HS remains obscure. Rupture of the lesion, suppuration, formation of sinus tracts and scarring may occur. It is characterized by firm, tender red nodules that soon become fluctuant and painful. The apocrine glands are the primary targets. Hidradenitis suppurativa is a chronic suppurative and scarring disease primarily affecting the axillae and inguinal and perineal areas. Condition or diseaseĭrug: drospirenone and ethinyl estradiol (YAZ) Drug: Placebo We use placebos in research studies to learn if the effects seen in research subjects are truly from the study drug or from other reasons. A placebo looks like the study drug but contains no active drug. Food and Drug Administration (FDA) to treat moderate acne in women who desire an oral contraceptive for birth control. It affects more women than men and HS often gets worse around the time a women has her menstrual period. Hormones seem to play a role in HS as the condition occurs after puberty. The progestin in YAZ actually blocks the male sex hormones (androgens) that cause acne. Sebaceous glands secrete an oily substance into a hair follicle to lubricate hair or skin. People who develop acne have sebaceous glands that are over-stimulated by male sex hormones (androgens). YAZ contains ethinyl estradiol (an estrogen) and drospirenone (a progestin). Nearly all birth control pills are made up of a combination of estrogen and progestin hormones. However, none of the medications are consistently effective. Many of the medications used for treating acne are also used for HS. However, it is believed that the plugging of hair follicles and bacterial infection that occur in acne also occur in HS. Scarring may result after several attacks of the disease.

It appears as blackheads and one or more red, tender bumps that may enlarge, break open, and drain pus.

Yaz birth control skin#

Hidradenitis suppurativa (HS) is a chronic (long lasting) skin disorder that mostly affects the armpits and groin area. The purpose of this study is to find out if taking a birth control pill, YAZ, is safe and effective for treating hidradenitis suppurativa. Why Should I Register and Submit Results?.